Iggy Pop led the tributes to the singer, posting "Mark Lanegan, RIP, deepest respect for you. Your fan, Iggy Pop"
Lanegan's former bandmate in Screaming Trees, Mark Pickerel, wrote "May you truly Rest In Peace Big Brother" and posted Lanegan's 1999 cover of Brook Benton's I'll Take Care Of You with the caption "I hope the angels are taking good care of you today"
The Velvet Underground's John Cale wrote, "I can't process this. Mark Lanegan will always be etched in my heart - as he surely touched so many with his genuine self, no matter the cost, true to the end. xx jc"
Guns N' Roses bassist Duff McKagan, another close friend, posted: "He was such a good man, and friend to my family. RIP Mark Lanegan"
Perhaps the most poignant tribute came from Lanegan's dear friend and former room-mate, The Afghan Whigs frontman Greg Dulli, who recorded with Lanegan as The Gutter Twins, who simply posted a photo of the pair together.
One of rock's greatest voices, Lanegan leaves behind an astonishing body of work: here's how peers, friends and fans from across the musical spectrum reacted to his passing.
pic.twitter.com/82rmY5l3oJFebruary 22, 2022
MESSAGE FROM IGGY:Mark Lanegan, RIP, deepest respect for you. Your fan, Iggy PopFebruary 22, 2022
I hope the angels are taking good care of you today @marklanegan https://t.co/rXhAJJFDUNFebruary 22, 2022
I can't process this. Mark Lanegan will always be etched in my heart - as he surely touched so many with his genuine self, no matter the cost, true to the end. xx jc pic.twitter.com/VDL176nbJuFebruary 22, 2022
I don’t want this to be real. He took care of me in a way very few people have. He would jump into the fire right next to you. The best friend you could want. I already miss him. World lost Mark Lanegan poet and singer. I lost my big brother. pic.twitter.com/AbQtiwPJOWFebruary 23, 2022
Bye Mark I’ll miss youThis is truly sadThat voice soothed us all pic.twitter.com/tF1Se9HoK3February 23, 2022
2022-02-22 - ”One story ends, another is born.”In the final hours of my wedding day I got the message of the passing of Mark Lanegan. A man that without knowing it held my head over the waterline in the beginning of the millennium with his words and music. pic.twitter.com/P3Xk7aZTmEFebruary 23, 2022
Mark Lanegan was a lovely man. He led a wild life that some of us could only dream of. He leaves us with fantastic words and music! Thank god that through all of that he will live forever. RIP Mark. Sleep well. Love Hooky. X pic.twitter.com/Xnx76y68YCFebruary 22, 2022
Devastating news. What a talent. Will be listening to Bubblegum for the rest of the day https://t.co/ySPCyY0GghFebruary 22, 2022
My brother, my mentor, my pen pal, my great friend. I can’t believe you’re gone my friend. I love you Mark Lanegan. And I thank him for everything, for our friendship and the inspiration. I loved him so much. He was the greatest. The very best of us xxFebruary 22, 2022
RIP Mark Lanegan. I was honoured to contribute a lyric and vocal on Rob Marshall's "Humanist" album alongside Mark and other notable artists... Huge Loss RS pic.twitter.com/HL7zLoV16uFebruary 22, 2022
Mark Lanegan rest easy mate. A real singer. ❤️February 22, 2022
Terribly saddened to hear the news of the passing of Mark Lanegan. A very gifted artist blessed with honey dipped tones, gone far too soon.February 22, 2022
Oh no. Terrible news that Mark Lanegan has left us. Safe travels man - you’ll be missed 💔February 22, 2022
My heartfelt condolences to the surviving family and fans of the immense talent that was Mark Lanegan. 🖤🖤☯️♾February 22, 2022
Rest in peace Mark LaneganFebruary 22, 2022
Fuck. Mark Lanegan now?February 22, 2022
Hearing about Mark Lanegan passing away has properly stopped me in my tracks. I’m absolutely gutted. Met him on a couple of occasions and I was nervous because I loved him so much. He was a perfect gentleman, really kind. One of THE great singers of the last 30 years. So sad 💔February 22, 2022
I am so profoundly grateful to have had the chance to make music & become friends with Mark Lanegan. Few artists ever achieve the level of honesty & authenticity that he did.He was absolutely brilliant.Godspeed my friend. 🖤February 22, 2022
Rest In Peace, old friend. Truly. More and more the best are no longer with us. @marklanegan pic.twitter.com/KPyPC17xadFebruary 22, 2022
Right now I'm thinking of Mark Lanegan and all the great music and performances he gave us. A few years back I contributed this to a 'My Favourite Gig' book, on his magnificently road-wrecked and defiant Alhambra show in 2015. Sending love to all his family, friends, and fans✨ pic.twitter.com/ho2yr63NVBFebruary 22, 2022
We are seeing the sad news that the remarkable Mark Lanegan has passed away. His voice was one of a kind…it reached into your soul and pulled your heart out. He was truly unique and will be greatly missed... pic.twitter.com/CL81KUPHUUFebruary 22, 2022
Mark Lanegan was a supremely gifted performer, songwriter, artist and author, and we are devastated to hear he has passed away. He will be deeply missed. His art will endure and only grow in stature. This is a colossal loss and our thoughts are with his family at this time. https://t.co/maXVCzcjBb pic.twitter.com/GpsRAubRoYFebruary 22, 2022